Senti Biosciences’ Breakthrough Cancer Treatment Sends Stock Soaring
A Potential Game-Changer in Cancer Therapy
Senti Biosciences, Inc. (NASDAQ:SNTI) has made a significant breakthrough in the fight against cancer, sending its stock price skyrocketing on Monday. The company’s innovative cancer treatment, SENTI-202, has shown remarkable results in a Phase 1 clinical trial, sparking a surge in investor interest.
SENTI-202: A Novel Approach to Cancer Treatment
SENTI-202 is a Logic Gated off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cell therapy designed to target and eliminate CD33 and/or FLT3-expressing hematologic malignancies, including acute myeloid leukemia (AML). This revolutionary treatment has the potential to selectively target cancer cells while sparing healthy bone marrow cells.
Impressive Clinical Trial Results
In the Phase 1 trial, three AML patients were treated with SENTI-202 at the lowest dose level (1.0 billion CAR+ NK cells per dose). As of the data cutoff date, two patients achieved complete remission, confirmed by bone marrow biopsy, and were assessed as measurable residual disease negative. Moreover, both patients maintained remission for over four months and three months, respectively.
Safety Profile and Next Steps
SENTI-202 demonstrated a favorable safety profile, with no dose-limiting toxicities and an adverse event profile consistent with other investigational NK cell therapies. The company plans to enroll approximately 20 patients in the Phase 1 trial, with a higher dose cohort of 1.5 billion CAR+ NK cells/dose currently enrolling. Additional safety and efficacy data, including initial durability data, are expected in 2025.
Financing and Leadership Updates
Concurrently, Senti Biosciences announced a private investment in public equity financing, raising approximately $37.6 million. The company also appointed Fran Schulz, an experienced biotechnology and financial executive, to its Board of Directors, replacing Omid Farokhzad.
Market Reaction
SNTI stock surged 439% to $11.66 on Monday, reflecting the excitement surrounding SENTI-202’s promising results. As investors continue to digest the news, Senti Biosciences’ stock is poised for further growth.
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